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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lower panobinostat degrees by ~70% and bring on therapy failure.pentobarbital will minimize the extent or outcome of eltrombopag by influencing hepatic enzyme CYP2C9/ten metabolism. Use Warning/Keep a